The prospect that Americans will receive the swine flu vaccine in time to protect them from this second wave of the U.S. epidemic continues to dim. With the pandemic virus showing "widespread activity" in 47 states—six more than a week ago—the Centers for Disease Control and Prevention now concedes that many people will become infected before they have a chance to get the shot. "The vaccine will arrive too late for many," CDC Director Thomas Frieden said at a press conference this afternoon. But he noted that a third wave of disease may occur next winter, by which time there should be ample vaccine available.